Hormone receptors and obesity in Japanese women with breast cancer

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Abstract
An association between hormone receptors in primary breast cancer and obesity determined prior to mastectomy was investigated in 128 Japanese women. The following criteria for obesity were used: (1) weight ≥60 kg (132 lbs), (2) weight kg/height cm−105 ≥ 1.3, (3) weight lbs/height in ≥2.30, (4) body surface area ≥1.56 m2. In view of the 4 criteria, tumor estrogen receptor (ER) values ≥ 4 fmol/mg were observed in obese patients more often than in nonobese patients, though the difference was not statistically significant. The same tendency was observed in the postmenopausal subgroup, 62 patients, especially in the 36 patients more than 5 years beyond menopause. However, there was still no statistical difference between obese and nonobese patients because the number of subjects was small. The same tendency was observed in the case of progesterone receptor (PgR) (≥6 fmol/mg) as observed in the case of ER.