Der Einfluß von Vitamin D3auf die Aktivität des Thyreocalcitonins in Rattenschilddrüsen

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Abstract
The amount, in terms of activity, of thyrocalcitonin in thyroid extracts of rats subjected to different doses of vitamin D3 injected for a long period of time was determined. Under low doses of vitamin D3 (up to approximately 10000 IU) normocalcemia in the animals can be maintained by increased secretion of thyrocalcitonin from the thyroid gland; the amount of thyrocalcitonin depends on the dose of vitamin D. Higher doses of vitamin D3 cause a complete depletion of thyrocalcitonin in the thyroid gland, and typical symptoms of hypervitaminosis in the form of a hypercalcemia appear. With these findings an attempt has been made to explain the physiologically paradoxical effect of vitamin D3 in high doses resulting primarily in a decalcification of bone.

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