INTERRUPTION OF PREGNANCY, INDUCTION OF OVULATION AND DELAYED PSEUDOPREGNANCY FOLLOWING SUPPRESSION OF LUTEAL FUNCTION

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Abstract
The responses of rats to acute luteal insufficiency induced by ergocornine or by luteectomy (removal of the functional corpora lutea) on 3 different days of pregnancy were compared. Both treatments interrupted pregnancy; estrus and ovulation recurred, followed usually by a pseudopregnancy. Weights of the adrenals, pituitary and pineal were not affected. Suppression of luteal secretion causes an increase of gonadotrophin secretion as well as sensitization of follicles to gonadotrophic stimulation which lead to ovulation. The corpora lutea formed at this ovulation usually become functional, suggesting the persistance of luteotrophic secretions despite the recurrence of ovulation.