Coagulation, Hemorrhage and Thrombosis
- 31 March 1955
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 252 (13) , 526-535
- https://doi.org/10.1056/nejm195503312521305
Abstract
Clinical ConsiderationsThe physician is thoroughly aware that prothrombinopenia causes retarded thrombin formation (elevated prothrombin time), which can result in hemorrhagic phenomena. Likewise, deficiency of accelerator globulin or of serum prothrombin conversion accelerator causes hemostatic disability. More significantly, the clinical manifestations of all these disorders are practically identical. This is not surprising since each leads to inadequate thrombin elaboration. Details may be obtained from certain exhaustive clinicolaboratory studies.43,44,144 This newer knowledge permits reclassification (Table 3) of the general hypoprothrombinemias into two major groups — true hypoprothrombinemia and pseudohypoprothrombinemia. The cardinal laboratory abnormality common to all, and serving to distinguish these . . .Keywords
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