Laboratory and Clinical Experience with Carbomycin

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Abstract
CARBOMYCIN is a new antibiotic substance produced by a soil actinomycete, Streptomyces halstedii. The isolation, purification and characterization of its physical and chemical properties have been accomplished by the workers from the Pfizer Research Laboratories.1 It is a crystalline, monobasic substance containing carbon, hydrogen and nitrogen with a molecular weight of about 860. The free base is only slightly water soluble, but dissolves readily in organic solvents. Acid salts such as the hydrochloride, phosphate or sulfate are prepared readily and are water soluble. Low degrees of both acute and chronic toxicity were noted for animals, including dogs, after both . . .