Development of Gluconeogenic Enzymes in the Liver of Human Newborns

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Abstract
Hepatic activities of fructose diphosphatase, pyruvate carboxylase and phosphoenolpyruvate carboxykinase (PEPCK) were measured as a function of age in premature or full-term infants: 41 postmortem samples and four biopsies from living children. All three enzymic activities were found to increase during the first 10 days of life, particularly PEPCK which may then be postulated to bear an important function in the postnatal regulation of blood sugar levels. The development of PEPCK activity begins after a lag period of 4–5 days after birth. The possible influence of prematurity and glucose infusions on the time course of PEPCK induction is discussed.

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