Clethramycin, a New Inhibitor of Pollen Tube Growth with Antifungal Activity from Streptomyces hygroscopicus TP-A0623 II. Physico-chemical Properties and Structure Determination

1 January 2003

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 56 (8) , 705-708
https://doi.org/10.7164/antibiotics.56.705

Abstract

Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. Clethramycin shows potent antifungal and pollen tube growth inhibitory activity.

Keywords

This publication has 0 references indexed in Scilit: