Cardiovascular actions of substituted adenosine analogues

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Abstract
1 The effects of adenosine on systemic blood pressure, coronary blood flow and cardiac contractility and rate were studied in anaesthetized open-thorax dogs. 2 The potency and duration of action of substituted adenosine analogues were compared with that of adenosine. 3 With the exception of 2-chloroadenosine, in which coronary dilator activity was enhanced, substitution in the 2-position of the adenosine molecule reduced activity. 4 In all cases 2-substitution prolonged the duration of the coronary dilator activity of adenosine. 5 N6-Methylation of adenosine and 2-chloroadenosine reduced their coronary dilator activities, but had no effect on the duration of the response. 6 Comparison of the coronary dilator potencies and hypotensive activities of 2-ethylaminoadenosine and 2-methoxyadenosine indicates that these analogues have some specificity for the coronary bed.