Studies on in vivo Priming of the TNP-Reactive Cytotoxic Effector Cell System
Open Access
- 1 July 1979
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (1) , 423-425
- https://doi.org/10.4049/jimmunol.123.1.423
Abstract
A comparison was made of the effects of i.v. inoculation of trinitrophenyl-(TNP) conjugated syngeneic cells on the subsequent in vitro generation of TNP-reactive effector cell activity and on the in vivo development of TNP-contact sensitivity. The administration of syngeneic TNP-conjugated spleen cells before 2,4,6-trinitro-1-chlorobenzene (TNCB) painting abolished the capability of animals to develop TNP-contact sensitivity. In contrast, the same treatment resulted in an appreciable augmentation in the generation of TNP-reactive cytotoxic effector cell activity as measured by subsequent in vitro sensitization with TNP-conjugated cells. The possible mechanisms by which enhanced TNP-reactive cytotoxic effector cell activity was elicited under conditions identical to those that induced unresponsiveness for TNP-contact sensitivity are discussed.Keywords
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