Studies on hypersensitivity. II. Delayed hypersensitivity to denatured proteins in guinea pigs.

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  • 1 January 1959
    • journal article
    • Vol. 2  (1) , 64-70
Abstract
The capacity of denatured proteins to provoke anaphylactic sensitivity and delayed sensitivity in guinea pigs has been investigated. It has been found that heat-denatured proteins are as effective as native proteins in provoking delayed hypersensitivity to either material, in spite of the fact that such denaturation greatly modifies their antigenicity from the point of view of antibody production. Pure delayed hypersensitivity, moreover, occurs regularly in response to extremely minute amounts of a good antigen, whether native or denatured.