INDUCTION OF HYPOTHERMIA IN MICE BY SEMI-ARTIFICIAL CELLS CONTAINING INDOLYL-3-ALKANE α-HYDROXYLASE

1 January 1979

journal article
Published by Wolters Kluwer Health in Asaio Journal

Vol. 25 (1) , 39-44
https://doi.org/10.1097/00002480-197902500-00008

Abstract

The administration of red cell ghost encapsulated indolyl-3-alkane alpha-hydroxylase (an enzyme which destroys tryptophan by oxidation of the side chains) in CD-1 female mice causes effective tryptophan depletion in plasma and brain and induces hypothermia by probably decreasing the serotonin concentration in brain by decreasing the concentration of its precursor, L-tryptophan.

Keywords

HYPOTHERMIA
ALKANE
BRAIN
INDOLYL
HYDROXYLASE
INDUCTION
SEROTONIN
ENCAPSULATED
DESTROYS
GHOST

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