Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer‐Diseased Brains

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Abstract
Samples of brain anterior temporal cortex from 17 patients with Alzheimer's disease and 18 age-matched controls have been analysed for myo-inositol and the three phosphoinositides. There was significantly less phosphati-dylinositol in the Alzheimer samples (1.36 μmol/g wet weight) than in the controls (2.28 μmol/g). The concentrations of phosphatidylinositol 4-phosphate and phosphati-dylinositol 4,5-bisphosphate were also lower in Alzheimer cortex, but differences from the control group were not statistically significant. Free myo-inositol concentrations were 5.11 μmol/g (Alzheimer) and 4.44 μmol/g (control) and again the difference was not significant. The lack of phosphoinositides in Alzheimer temporal cortex may impair receptor function.

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