Possible Synergistic Effects of the New Thymoleptics in Connection with Poisoning

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Abstract
During recent years, a good deal of attention has been drawn to the therapeutic and toxic effects of the new thymoleptics. Although most of these preparations have had a reasonable clinical trial before being released for general use, it is a fact that hitherto unsuspected toxic effects continue to come to light. Among the more recently discovered side-effects of Tofranil (imipramine) are the occurrence of jaundice and a tendency in certain patients to epileptic fits. Experimentally it has been shown that Tofranil increases the excitability of the brain of rabbits and may evoke convulsant spikes (1), and in a recent article by Leyberg and Denmark (2) it is recorded that in four cases of a relatively small series the dose of the drug had to be reduced on account of epileptic fits.

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