EVALUATION AND CORRELATION OF HORMONE LEVELS IN NORMAL AND PATHOLOGIC PREGNANCIES

  • 1 January 1984
    • journal article
    • research article
    • Vol. 5  (4) , 143-148
Abstract
The disadvantages of estriol [E3] monitoring are the inaccuracy of a 24 h urine sample and the delay of 2 days. The advantages are a possible high variation of serum hormone evaluations from a very short sampling period. To prove the reliability of serum hormone patterns in pathological pregnancies, they were compared to 24 h urinary E3 patterns. Free E3 and HCS [human chorion-somatomammotropin] levels were determined in serum samples by radioimmunoassays. Total 24 h urinary E3 was determined by a procedure according to Frandsen. For the graphic presentation, hormone levels from each pregnancy were grouped weekly and the mean values .+-. SD in the different weeks of gestation were computed. To estimate the tendency of hormone patterns Z-transformation of grouped single hormone evaluations was performed. A comparison between the serum and urine E3 measurements showed similar hormone patterns. E3 hormone patterns measured either in urine or serum proved to be well comparable. The mean of the transformed values showed the tendency of the hormone patterns even more distinctly than the graphic presentation. The hormone parameters E3 and HCS for monitoring high-risk pregnancies should be rated according to the diseases. In cases of placental insufficiency, E3 seemed to be the more sensitive parameter, whereas in severe cases of EPH [edema, proteinura hypertension]-gestosis HCS might be more reliable.

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