INDUCTION OF DECIDUOMATA IN HAMSTER AND RAT BY INJECTED AIR

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Abstract
Air, (.05 ml.) injected into the ovarian end of the uterine lumen of the golden hamster during the fourth day of pseudopregnancy (3 days and 9-22 hours post-ovulation) results in deciduomata resembling normal conceptual swellings of comparable post-ovulation age, (6 days and 12 hours). The development of the deciduomata can be followed in benzyl-benzoate cleared specimens. On the day of trauma localized bubbles within the lumen mark the site of the air. By 24 hours post-trauma localized opacities appear; these and subsequent stages resemble in gross morphology and pattern of opacity normal gestational sites of comparable post-ovulation age. Twelve rats, made pseudo-pregnant by cervical stimulation and similarly injected with .05 or .10 ml. of air at 10 A.M. of the 4th day of diestrus show similar early luminal air distension, and, by 96 hours post-trauma, decidualization varying from single descrete swellings to lobulated or solid deciduoma. The descrete deciduomata resemble comparably aged pregnancies. Three of 9 rats injected unilaterally showed 1-4 distinct deciduomata in the uninjected horn. No such phenomena in the uninjected horn have ever been observed in the hamster. Sensitivity to air induction is limited to the immediate pre-implantation period. Traumatic induction by thread insertion is possible earlier.