Modification of Gramicidin Through Reaction with Formaldehyde
- 14 September 1945
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 102 (2646) , 274-275
- https://doi.org/10.1126/science.102.2646.274
Abstract
Treating tyrothrycin with formaldehyde caused a loss of 80-90% of hemolytic activity and up to 50% of the antibiotic activity. Treating gramicidin with formaldehyde similarly reduced hemolytic activity but antibiotic activity, estimated with Staphylococcus aureus, was unchanged. Modified gramicidin lost considerable toxicity.This publication has 6 references indexed in Scilit:
- Production of Tyrothricin in Cultures of Bacillus brevisIndustrial & Engineering Chemistry, 1945
- The Reaction of Formaldehyde with ProteinsJournal of the American Chemical Society, 1945
- PenicillinJournal of Bacteriology, 1944
- The effect of formaldehyde and mercuric chloride on tobacco mosaic virusBiochemical Journal, 1944
- A QUANTITATIVE METHOD FOR THE DETERMINATION OF TYROTHRICINPublished by Elsevier ,1943
- THE PARTIAL REACTIVATION OF FORMOLIZED TOBACCO MOSAIC VIRUS PROTEINThe Journal of general physiology, 1938