The α-Specific Cell Identity Factor Sxi1α Is Not Required for Virulence of Cryptococcus neoformans
Open Access
- 1 June 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (6) , 3643-3645
- https://doi.org/10.1128/iai.72.6.3643-3645.2004
Abstract
Cryptococcus neoformans is a human fungal pathogen that has two mating types ( a and α). Experiments have shown that in some backgrounds α strains are more virulent than a strains. Our studies reveal that the only known α-specific factor, SXI1 α, is not necessary for virulence.Keywords
This publication has 15 references indexed in Scilit:
- Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α IsolatesInfection and Immunity, 2003
- Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1αGenes & Development, 2002
- A PCR-based strategy to generate integrative targeting alleles with large regions of homologyMicrobiology, 2002
- Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinctProceedings of the National Academy of Sciences, 2000
- Cryptococcus neoformansPublished by American Society for Microbiology ,1998
- Molecular epidemiology of Cryptococcus neoformans in Brazil and the United States: evidence for both local genetic differences and a global clonal population structureJournal of Clinical Microbiology, 1997
- Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type.Proceedings of the National Academy of Sciences, 1996
- Genetic association of mating types and virulence in Cryptococcus neoformansInfection and Immunity, 1992
- DISTRIBUTION OF α AND α MATING TYPES OF CRYPTOCOCCUS NEOFORMANS AMONG NATURAL AND CLINICAL ISOLATESAmerican Journal of Epidemiology, 1978
- Morphogenesis ofFilobasidiella Neoformans, the Sexual State ofCryptococcus NeoformansMycologia, 1976