RADIATION-INJURY IN NEONATAL CANINE KIDNEY .2. QUANTITATIVE MORPHOLOGY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 38  (3) , 225-231
Abstract
Quantitative morphology was used to investigate injury induced in the developing canine kidney by ionizing radiation. Irradiation at 2 days of age destroyed nephrogenic tissue in the outer renal cortex and significantly reduced kidney weight and volume through 70 days of age. As early as 14 days of age and continuing through 200 days of age, hypertrophy was demonstrated in the surviving middle and inner cortical nephrons of these kidneys. Corpuscular and tubular components of nephrons grew at an accelerated rate as compared to controls. Corpuscular volume per nephron increased 559% in irradiated dogs and only 249% in controls from 14-200 days of age. Tubular volume per nephron increased 519% in irradiated dogs and 303% in controls during the same period. As a result of compensatory growth in individual nephrons, kidneys of irradiated dogs at 200 days of age were as large as controls when compared on the basis of body weight. Extensive hypertrophy is associated with accelerated development of intercapillary glomerulosclerosis in dogs irradiated around the time of birth.

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