Mechanism of Anaphylaxis in the Rabbit. Further Evidence Against Plasma Protease Mechanism.

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Abstract
The plasma protease theory of the mechanism of anaphylaxis in the rabbit appears untenable because: (1) Homologous antigen will release histamine in vitro or will produce fatal anaphylaxis in vivo without significant activation of plasma protease. (2) Streptokinase will activate plasma protease both in vitro and in vivo without producing any symptoms of anaphylaxis in vivo or releasing any histamine from the blood cells in vitro.