Pleomorph poorly differentiated endocrine carcinoma of the rectum
- 7 May 2003
- journal article
- case report
- Published by Springer Nature in Virchows Archiv
- Vol. 442 (6) , 605-610
- https://doi.org/10.1007/s00428-003-0807-1
Abstract
We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.Keywords
This publication has 10 references indexed in Scilit:
- Efficacy and Safety of Imatinib Mesylate in Advanced Gastrointestinal Stromal TumorsNew England Journal of Medicine, 2002
- Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectumVirchows Archiv, 2002
- Different patterns of 11q allelic losses in digestive endocrine tumorsHuman Pathology, 2002
- Imatinib Mesylate — A New Oral Targeted TherapyNew England Journal of Medicine, 2002
- p27: A potential main inhibitor of cell proliferation in digestive endocrine tumors but not a marker of benign behaviorHuman Pathology, 2001
- Histological Typing of Endocrine TumoursPublished by Springer Nature ,2000
- ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: Prognostic evaluation by pathological analysisGastroenterology, 1999
- Progress in understanding the molecular pathogenesis of human lung cancerBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1998
- Sarcomatoid Carcinoma of the Anorectal Junction with Neuroendocrine and Rhabdomyoblastic FeaturesThe American Journal of Surgical Pathology, 1995
- Keratin immunohistochemistry: update of applications and pitfalls.1993