STUDIES ON THE DEVELOPMENT OF EXTRAMEDULLARY MARROW IMPLANTS Establishment of Allografts in Thymectomized Rats Treated with Antilymphocyte Serum

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Abstract
SUMMARY Rats thymectomized neonatally received allogeneic bone marrow implants from randomly bred normal donors and were treated on alternate days with antilymphocyte serum (ALS). Fifty-four percent of implants left in situ for 15 days or more developed into ossicles containing hemopoietic marrow. Allogeneic marrow implanted in rats which were either normal, neonatally thymectomized and not treated with ALS, or treated with ALS alone, with few exceptions failed to develop into marrow-containing ossicles. Initially their development was normal, with mesenchymal cell proliferation and early cancellous bone formation. Rejection of the implant then became evident with loss of osteoblasts, bone resorption, and failure of sinus development. As a result of this lack of microvascular regeneration, hemopoiesis did not occur.

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