Formation of Cyclobutane Thymine Dimers from UVA Photosensitization of Pyridopsoralen Monoadducted DNA
- 1 August 1996
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 64 (2) , 349-355
- https://doi.org/10.1111/j.1751-1097.1996.tb02470.x
Abstract
The present report provides evidence that thymine dimerization can be UVA photosensitized at a tetranucleotide, 5'-TATT-3', by a 7-methyl-pyrido(3,4-c)psoralen monoadduct in DNA. The efficiency of the photoprocess depends on the tetranucleotide flanking sequences. These results demonstrate that one DNA lesion can originate the contiguous formation of a second type of lesion and emphasize the sequence-specific response to interaction of drugs with DNA. Results are related to the sensitivity of DNA to 1,10-phenanthroline-cuprous ion complex nucleolytic activity and discussed in terms of the major role of local deformability of DNA in interaction with ligands.Keywords
This publication has 31 references indexed in Scilit:
- SELECTIVE DNA THYMINE DIMERIZATION DURING UVA IRRADIATION IN THE PRESENCE OF A SATURATED PYRIDOPSORALENPhotochemistry and Photobiology, 1995
- DETECTION OF PYRIMIDINE DIMERS AND MONOADDUCTSINDUCED BY 7‐METHYLPYRIDO(3,4‐c) PSORALEN AND UVA IN CHINESE HAMSTER V79 CELLS BY ENZYMATIC CLEAVAGE AND HIGH‐PRESSURE LIQUID CHROMATOGRAPHYPhotochemistry and Photobiology, 1994
- Alternative structures for alternating poly(dA-dT) tracts: the structure of the B-DNA decamer C-G-A-T-A-T-A-T-C-GBiochemistry, 1992
- Structure of a B-DNA decamer with a central T-A step: C-G-A-T-T-A-A-T-C-GJournal of Molecular Biology, 1992
- Sequence specificity of the deoxyribonuclease activity of 1,10-phenanthroline-copper ionBiochemistry, 1990
- DNA Repair EnzymesAnnual Review of Biochemistry, 1988
- Sequence context effects on 8-methoxypsoralen photobinding to defined DNA fragmentsBiochemistry, 1987
- Nuclease activity of 1,10-phenanthroline-copper ion: reaction with CGCGAATTCGCG and its complexes with netropsin and EcoRIBiochemistry, 1986
- Psoralens as Photoactive Probes of Nucleic Acid Structure and Function: Organic Chemistry, Photochemistry, and BiochemistryAnnual Review of Biochemistry, 1985
- Synthesis of 5H-furo[3′,2′ : 6,7][1]benzopyrano[3,4-c]pyridin-5-ones and 8H-pyrano[3′,2′ : 5,6]benzofuro[3,2-c]pyridin-8-ones (pyridopsoralens)Journal of the Chemical Society, Perkin Transactions 1, 1983