EFFECT OF TESTOSTERONE ON SERUM PROLACTIN IN THE CASTRATED RAT

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Abstract
Department of Physiology, Queen's University, Kingston, Ontario, Canada K7L 3N6 (Received 20 May 1974) It is well established that gonadal steroid hormones stimulate prolactin secretion and increase the level of prolactin in the blood (Meites, Lu, Wuttke, Welsch, Nagasawa & Quadri, 1972). Many studies of the factors affecting the level of prolactin in the blood have been performed with anaesthetized rats (Chen & Meites, 1970; Wuttke & Meites, 1970; Kalra, Fawcett, Krulich & McCann, 1973). However, since it is now reasonably well established that anaesthetic agents can change levels of prolactin in the circulation (Wakabayashi, Arimura & Schally, 1971; Ajika, Kalra, Fawcett, Krulich & McCann, 1972; Terkel, Blake & Sawyer, 1972), we decided to re-examine the effect of gonadal steroids upon plasma levels of prolactin in the unanaesthetized rat. Animals were castrated and prolactin levels were determined at three intervals with and without the administration of testosterone. Young male rats

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