Metabolism of cathinone to (−)-norephedrine and (−)-norpseudoephedrine
- 1 April 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (4) , 298-300
- https://doi.org/10.1111/j.2042-7158.1986.tb04571.x
Abstract
S-(−)-Cathinone (S-(−)-α-aminopropiophenone) is the major active principle of khat leaves (Catha edulis), which are widely used in East Africa and the Arab peninsula as an amphetamine-like stimulant. After oral administration of synthesized cathinone (isomers, racemate), 22–52% was recovered in 24 h urine samples mainly as aminoalcohol metabolites. With GC/MS, HPLC and CD, the main metabolite of S-(−)-cathinone was identified as R/S-(−)-norephedrine and the main metabolite of R-(+)-cathinone as RR-(−)-norpseudoephedrine. Both aminoalcohols are formed by a stereospecific keto reduction.This publication has 12 references indexed in Scilit:
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