Organic solvents inhibit the mutagenicity of promutagens dimethylnitrosamine and methylbutylnitrosamine in a higher plant Arabidopsis thuliana
- 1 January 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Mutagenesis
- Vol. 1 (2) , 107-109
- https://doi.org/10.1093/mutage/1.2.107
Abstract
The organic solvents dimethylsulphoxide (DMSO), acetone, ethanol and dimethylformamide inhibited the mutagenic activity of the promutagens dimethylnitrosamine and methylbutylnitrosamine in a higher plant Arabidopsis thaliana. In contrast, the direct-acting mutagens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU) were not affected by the organic solvents (with the exception of DMSO). The effect of DMSO on MNNG- and MNU-mutagenesis is explained by its effect on the pH of the mutagenic solution. The results support the assumption that the activation of promutagenic nitrosamines in A. thaliana proceeds by the same, or similar, mechanisms to that in ‘animal’ activation.This publication has 2 references indexed in Scilit:
- Screening of compounds for antimutagenic properties towards dimethylnitrosamine-induced mutagenicity inArabidopsis thalianaBiologia plantarum, 1985
- Somatic crossing-over in glycine max (L.) merrill: Activation of dimethyl nitrosoamine by plant seed and comparison with methyl nitrosourea in inducing somatic mosaicismMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978