Inhibition of Mouse Ascites Tumors by Carbohydrate Combined with Immunization

Publisher Website
Google Scholar
Abstract
Mice, inoculated intraperitoneally with TA3 ascites tumor cells, received intraperitoneal injections of D-mannose, D-glucosamine, 2-deoxy-D-glucose, and DL-glyceraldehyde. With daily single injections for 10 days, D-mannose produced no effect; D-glucosamine reduced the total tumor volume but not the packed cell volume; 2-deoxy-D-glucose caused a moderate reduction in both the tumor fluid and the packed cell volume; and DL-glyceraldehyde reduced the tumor development drastically. With multiple injections on a single day, 2-deoxy-D-glucose produced no effect; D-glucosamine caused a moderate inhibition of tumor growth; and DL-glyceraldehyde strongly inhibited the tumor development. The inhibitory effect of DL-glyceraldehyde was greatly enhanced by the previous immunization of the mice with an insoluble fraction prepared from the tumor cells. The potentiating effect of DL-glyceraldehyde and immunization was found also with the Ehrlich, Ehrlich-Lettré, 6C3HED, and SAI mouse ascites tumors. DL-Glyceraldehyde was toxic to mice with an LD50 of 3.0 g/kg. Mice, injected intraperitoneally with 1.0% DL-glyceraldehyde solution, developed enlarged livers which showed excessive amounts of cytoplasmic glycoprotein granules.

This publication has 0 references indexed in Scilit: