The predictive value of crossmatching platelet transfusion for alloimmunized patients

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Abstract
To determine the predictive value of a radiolabeled antiglobulin test for platelet crossmatching to select platelets for transfusion, 230 transfusions in 42 alloimmunized oncology patients were evaluated. Transfusions were classified according to the degree of HLA match. The value of the crossmatch in predicting platelet transfusion outcome was analyzed for each HLA category. For predicting the 1-h corrected platelet count increment of all transfusions, the sensitivity of the test was 86%, specificity 84% and total predictive value 84%. The crossmatch technique had similar predictive ability in all categories of HLA match, whether analyzing the results on the basis of the 1- or 24-h platelet count rise.