CELLULAR CONTROL OF DELAYED-HYPERSENSITIVITY TO STAPHYLOCOCCUS-AUREUS IN MICE

Google Scholar
  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (1) , 103-108
Abstract
Cells which suppressed delayed hypersensitivity (DH) to S. aureus in mice were non-phagocytic, adhered to nylon wool and possessed surface immunoglobulin but no detectable Thy 1.antigen. They were probably B [bone-marrow-derived] lymphocytes and the suppression which they mediated appeared specific. Mature suppressor cells were radiosensitive. Their precursors were sensitive to large cyclophosphamide doses. Suppressor-cell activity in the spleen reached a peak after 2 s.c. S. aureus infections and declined thereafter. This decline might be related to appearance of DH to S. aureus in mice after 4 or more staphylococcal infections.