A plasma‐membrane progesterone receptor in human sperm is switched on by increasing intracellular free calcium
- 6 September 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 330 (1) , 57-60
- https://doi.org/10.1016/0014-5793(93)80919-l
Abstract
Recent studies have revealed the presence of an atypical progesterone receptor on the plasma membrane of a relatively small subpopulation of human sperm cells. In this study, we show that the receptor is present in many cells in a latent form and that the receptor function in these cells is switched on asynchronously by increasing intracellular free Ca2+ levels. Under physiological conditions, this process occurs during sperm capacitation, but it can be mimicked by a short sperm exposure to the Ca2+‐mobilizing agent thapsigargin. These observations suggest a role of Ca2+ as a modulator of nongenomic steroid effects on the cell surface.Keywords
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