Hydrogen-bonding effects and 13 of the DNA double helix
- 1 January 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (5) , 2323-2332
- https://doi.org/10.1093/nar/16.5.2323
Abstract
13C-nmr chemical shifts of the nucleotides in DNA are sensitive to hydrogen bonding, especially for three of the carbons immediately bonded to exocyclic oxygen or nitrogen atoms acting as H-bond acceptors or donors. GuoC2, GuoC6 and ThdC4 are strongly deshielded (about 1 ppm) upon Watson-Crick pairing in oligodeoxynucleotide duplexes, regardless of the base sequence. Deshielding at these sites may be useful to distinguish bases involved in Watson-Crick pairs from upaired bases.This publication has 29 references indexed in Scilit:
- Ab-initio Quantum Mechanical Calculations of NMR Chemical Shifts in Nucleic Acid Constituents I The Watson-Crick Base PairsJournal of Biomolecular Structure and Dynamics, 1984
- Secondary structure in the solution conformation of the proteinase inhibitor IIA from bull seminal plasma by nuclear magnetic resonanceJournal of Molecular Biology, 1984
- Molecular structure of r(GCG)d(TATACGC): a DNA–RNA hybrid helix joined to double helical DNANature, 1982
- A model for base overlap in RNANature, 1982
- Syringe method for stepwise chemical synthesis of oligonucleotidesNucleic Acids Research, 1982
- The Anatomy of A-, B-, and Z-DNAScience, 1982
- Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG).Proceedings of the National Academy of Sciences, 1980
- Further refinement of the structure of yeast tRNAPheJournal of Molecular Biology, 1978
- Crystal structure of yeast phenylalanine transfer RNAJournal of Molecular Biology, 1978
- Conformation and interaction of short nucleic acid double-stranded helices. I. Proton magnetic resonance studies on the nonexchangeable protons of ribosyl ApApGpCpUpUBiochemistry, 1975