THE PREPARATION AND BIOLOGICAL EFFECTS OF IODINATED PROTEINS

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Abstract
INTRODUCTION That the thyroid gland is intimately concerned with the maintenance of milk secretion has been shown both by experiments involving the surgical removal of the gland, and by those in which the thyroid hormone has been administered to pregnant or lactating animals. Thyroidectomy in the lactating goat [Grimmer, 1918; Trautmann, 1919; Grimmer & Paul, 1930; Grueter, 1930] generally leads to a depression, though not a cessation of milk secretion, while in the lactating cow, thyroidectomy has been shown to reduce the lactation period and milk yield [Spielman, Petersen & Fitch, 1944]. Thyroid extirpation experiments, are, however, often complicated by the presence of accessory thyroid tissue, and opinion is still divided on the lactational effect of thyroidectomy in the rat [Nelson & Tobin, 1937; Folley, 1938; Nelson, 1939], so that the most convincing evidence of the role of the thyroid in lactation is to be found in those experiments in

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