The Content of Luteinizing Hormone of the Anterior Pituitary and of Luteinizing Hormone Releasing Factor of the Hypothalamus in Estrogen-Induced Persistent-Diestrous Rats

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Abstract
In persistent-diestrous rats secured by continued injections of estrogen for the first 30 days of the postnatal life, the ovarian ascorbic acid depleting potencies of the anterior pituitary and of the hypothalamus were significantly decreased as compared with those in normal females. The prolonged treatment with estrogen seems to have brought about an irreversible derangement in the regulatory mechanism of the production and release of LH-RF by the hypothalamus.