Globin Chain Synthesis Analysis by High Performance Liquid Chroniatography in the Screening of Thalassemia Syndromes
- 1 January 1998
- journal article
- Published by Taylor & Francis in Hemoglobin
- Vol. 22 (5-6) , 501-508
- https://doi.org/10.3109/03630269809071547
Abstract
We applied reversed phase high performance liquid chromatography for globin chain synthesis analysis in screening for β-thalassemia. The α/non-α-globin chain synthesis ratios have been determined in α-, β-, and δβ-thalassemia carriers using the classical carboxymethyl cellulose chromatography as the reference method. Reversed phase high performance liquid chromatography is fast, accurate, and reproducible, and may be a suitable alternative for the traditional carboxymethyl cellulose chromatography.Keywords
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