Total Synthesis of Cribrostatin IV: Fine-Tuning the Character of an Amide Bond by Remote Control
- 10 March 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 127 (13) , 4596-4598
- https://doi.org/10.1021/ja050203t
Abstract
We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a “lynchpin” Mannich cyclization to establish the pentacyclic core (cf. 19 → 20).Keywords
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