A new type of silyl protecting groups in nucleoside chemistry
- 1 January 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 5 (suppl_1) , s185-s190
- https://doi.org/10.1093/nar/1.suppl_1.s185
Abstract
A new type of silyl protecting group was designed and a reagent for its introduction was obtained. This reagent, 1,3--dihalo-1,1,3,3-tetraalkyldisiloxane, allows simultaneous protection of 3′-OH and 5′-OH groups of nucleoside in high yield. The properties of the new protecting group were studied and some aspects of its applications are presented.Keywords
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