EFFECT OF TRICHLOROPROPENE OXIDE AND BENZOFLAVONE ON POLYCYCLIC-HYDROCARBON CARCINOGENESIS IN C3H-HE AND DBA-2 MICE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 70  (1) , 83-87
Abstract
Effect of 1,1,1-trichloropropene 2,3-oxide and 7,8-benzoflavone on benzo[a]pyrene and 3-methylcholanthrene carcinogenesis in the s.c. tissues of C3H/He and DBA/2 mice was examined. By a single application of the carcinogen, the incidence of fibrosarcoma was higher and the latency of tumorigenesis shorter in C3H/He mice than in DBA/2 mice. Treatment with 1,1,1-trichloropropene 2,3-oxide increased the incidence of fibrosarcoma in DBA/2 mice but decreased the rate in C3H/He mice, when benzo[a]pyrene was used as a carcinogen. In 3-methylcholanthrene carcinogenesis, no effect of the oxide on tumor incidence was observed. By the simultaneous application of 7,8-benzoflavone with benzo[a]pyrene, tumor incidence increased, but not as significantly in DBA/2 mice compared to those treated with benzo[a]pyrene alone. No appreciable effect was observed in C3H/He mice treated with benzo[a]pyrene or in both strains of mice with 3-methylcholanthrene. The relationship between the activity of arylhydrocarbon hydroxylase and the change in polycyclic hydrocarbon carcinogenesis is briefly discussed.