Block by Cs of K currenti K1 and of carbachol induced K currenti Cch in frog atrium

Publisher Website
Google Scholar
Abstract
1. In frog atrium, Cs ions block both the inward rectifieri K1 and the carbachol induced K currenti Cch. 2. Bothi K1 andi Cch display a high affinity for Cs with a K0.5 of 4×10−5 M fori k1 and of 8×10−5 M fori Cch atV=−50 mV. 3. Block of bothi K1 andi Cch is strongly voltage dependent. When fitted by the block model of Woodhull (1973), δ is >1 for the two currents. 4. From these similarities, action of Cch on frog atrium K permeability could be interpreted as a modification ofi K1.