Demonstration of pulsatile cerebrospinal-fluid flow using magnetic resonance phase imaging

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Abstract
The study of pulsatile cerebrospinal-fluid (CSF) flow may be useful in diagnosis of certain forms of intractranial disease. Previous techniques used to study CSF flow either are invasive or do not allow accurate measurement. Magnetic resonance imaging (MRI) offers a non-invasive method of studying the CSF pathways. Our technique used MR phase images and allows quantitative measurement of flow velocities and volume-flow rates. Four volunteers were studied at the level of the second cervical vertebra (C2). The MRI pulse sequence was gated from the R-wave of the subjects''s electrocardiogram and 12 scans were taken corresponding to different times in the cardiac cycle. The variation in flow velocity throughout the cycle was plotted, and maximum caudad and cephalad flow velocities and flow rates were calculated. Good agreement was found between three of the four volunteers. The mean maximum caudad velocity was 2.91 cm s-1 occurring at a mean time of 190 ms after the R-wave. This corresponds to a mean maximum flow rate of 4.13 ml s-1. The total imaging time for each study was about 1 h. Technical developments, allowing simultaneous acquistion of several images throughout the cardiac cycle, witll reduce this time significantly.