Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors
- 19 February 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (5) , 1265-1268
- https://doi.org/10.1016/j.bmcl.2003.12.040
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic PropertiesJournal of Medicinal Chemistry, 2003
- Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VIIBiochemical Journal, 2003
- Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treatment of Type 2 diabetesExpert Opinion on Therapeutic Patents, 2003
- Treatment of non-insulin-dependent diabetes mellitusExpert Opinion on Investigational Drugs, 2003
- Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetesExpert Opinion on Investigational Drugs, 2003
- New drug targets for type 2 diabetes and the metabolic syndromeNature, 2001
- Synthesis and biological evaluation of novel 1β-methylcarbapenems having a new moiety at C-2Bioorganic & Medicinal Chemistry Letters, 1999
- The first enantioselective syntheses of vicinal difluoropyrrolidines and the first catalytic asymmetric synthesis mediated by the C2 symmetry of a –CHFCHF– unitChemical Communications, 1998
- Pyrrolidides: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IVEuropean Journal of Medicinal Chemistry, 1997
- Facile and Efficient Syntheses of Novel (S)- and (R)-3-Fluoropyrrolidines and 3,3-DifluoropyrrolidineSynlett, 1995