A Protective Gene for Graft-versus-Host Disease

Publisher Website
Google Scholar
Abstract
Hematopoietic stem-cell transplantation is an effective but toxic therapy for a number of life-threatening diseases, especially hematologic cancers. The principal complication of allogeneic stem-cell transplantation (the transplantation of grafts from genetically different donors) is graft-versus-host disease (GVHD), which can occur despite aggressive immunosuppressive prophylaxis and even when the donor is a “perfectly” matched (HLA-identical) sibling. The complex pathophysiology of GVHD fundamentally depends on interactions between antigen-presenting cells of the recipient and mature T cells of the donor (see Figure). A substantial body of research in animal models has uncovered the contribution of cytokines to the inflammation and tissue damage that . . .

This publication has 0 references indexed in Scilit: