[Effect of cocarboxylase on hyperlactatemia and hyperpyruvicemia induced by phenformin in dogs].

  • 1 January 1975
    • journal article
    • abstracts
    • Vol. 169  (1) , 121-5
Abstract
In the normal anesthetized dog, a cocarboxylase perfusion considerably reduced the increase in blood lactate and pyruvate levels provoked by the intraduodenal injection of phenformin (30 mg/kg); furthermore it seems to counteract the increase of the lactates/pyruvates ratio and opposes the fall in blood pH.

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