Antihepatotoxic Actions of Ginsenosides fromPanax ginsengRoots1
- 26 February 1985
- journal article
- other
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 51 (01) , 62-64
- https://doi.org/10.1055/s-2007-969395
Abstract
The antihepatotoxic effects of ginsenosides, saponins from Panax ginseng, and their aglycones were investigated utilizing carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Prominent protective actions were found with 20(S)-ginsenoside-Rh2, 20(R)-ginsenoside-Rg3 and prosapogenin of ginsenoside-Ro, 20(R)- and 20(S)-ginsenoside-Rs in CCl4-produced cytotoxicity, and 20(S)-ginsenoside-Rh1 and prosapogenin of 20(S)-ginsenoside-Rs were effective in preventing GalN-induced liver cell damage. The antihepatotoxic effects of chikusetsusaponins, saponins of Panax japonicus, were also examined. The structure-activity relationship is discussed.Keywords
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