Influence of a Diverting Colostomy on Epithelial Cell Proliferation in the Colon of Rats

Publisher Website
Google Scholar
Abstract
The effect of a transverse colostomy was compared to a sham operation and to transsection of the colon with tranastomosis in rats. The autoradiographic study after labeling with 3H-thymidine showed a significant decrease in proliferative activity at 5 days and at 3 wk in the colonic segment distal to the colostomy. This observation was confirmed by the occurrence of mucosal atrophy and by a significant decrease in the mucosal DNA synthesis activity. The intraluminal presence of fecal bulk is an important factor in the maintenance of cell renewal in the colon of rats. Other factors seem, however, to be involved since a delayed but significant decrease in proliferative parameters was also observed proximal to the colostomy; no mucosal atrophy occurred in the latter segment.

This publication has 2 references indexed in Scilit: