Effect of B-15,000 (Iopamidol), A New Nonionic Contrast Agent, on Cardiac Function of the Isolated Rat Heart

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Abstract
The isolated rat heart model was used to examine the effect of a new nonionic contrast agent, B-15,000 (Iopamidol), on cardiac function. Comparative studies were performed with Amipaque, Renografin 60, Renografin 76 and Vascoray. The 3 ionic contrast agents had significantly greater detrimental effects on cardiac function than either nonionic agent. Nonionic agents should be further evaluated for use in coronary angiography.

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