The Lewy body in Parkinson's disease: Molecules implicated in the formation and degradation of α‐synuclein aggregates
Top Cited Papers
- 18 September 2007
- journal article
- review article
- Published by Wiley in Neuropathology
- Vol. 27 (5) , 494-506
- https://doi.org/10.1111/j.1440-1789.2007.00803.x
Abstract
The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. To date, more than 70 molecules have been identified in LBs, in which alpha-synuclein is a major constituent of LB fibrils. Alpha-synuclein immunohistochemistry reveals that diffuse cytoplasmic staining develops into pale bodies via compaction, and that LBs arise from the peripheral portion of pale bodies. This alpha-synuclein abnormality is found in 10% of pigmented neurons in the substantia nigra and more than 50% of those in the locus ceruleus in PD. Recent studies have suggested that oligomers and protofibrils of alpha-synuclein are cytotoxic, and that LBs may represent a cytoprotective mechanism in PD.Keywords
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