OxidativeN-Dealkylation: A Mannich Intermediate in the Formation of a New Metabolite of Lidocaine in Man
- 6 August 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 173 (3996) , 544-546
- https://doi.org/10.1126/science.173.3996.544
Abstract
Evidence is presented for a new metabolite of lidocaine. Its structure,N1-ethyl-2-methyl-N3-(2,6-dimethylphenyl)-4-imidazolidinone, suggests reactive electrophilic intermediates for the oxidative removal ofN-alkyl groups in general.Keywords
This publication has 6 references indexed in Scilit:
- The Mannich Reaction. Mechanistic and Technological ConsiderationsJournal of Pharmaceutical Sciences, 1968
- The metabolism and excretion of lignocaine in manJournal of Pharmacy and Pharmacology, 1966
- Microsomal Dealkylation of DrugsJournal of Pharmaceutical Sciences, 1966
- Detoxication of Drugs and Other Foreign Compounds by Liver MicrosomesScience, 1955
- Synthetic antimalarials. Part XLIX. The structure and synthesis of the dihydrotriazine metabolite of proguanilJournal of the Chemical Society, 1954
- PROGUANIL—THE ISOLATION OF A METABOLITE WITH HIGH ANTIMALARIAL ACTIVITYBritish Journal of Pharmacology and Chemotherapy, 1953