Inhibition of cathepsin K - a novel approach to antiresorptive therapy
- 1 September 1997
- journal article
- Published by Taylor & Francis in Expert Opinion on Investigational Drugs
- Vol. 6 (9) , 1199-1202
- https://doi.org/10.1517/13543784.6.9.1199
Abstract
Cathepsin K is a cysteine protease enzyme with high and specific expression in osteoclasts, the cells responsible for resorbing bone. Its discovery and the numerous lines of evidence that support a specialised role for cathepsin K in bone resorption are discussed. Inhibition of this enzyme would be anticipated to prevent bone resorption, and be of potential utility in diseases involving excess bone loss, such as osteoporosis. The pharmaceutical companies known to be involved in developing inhibitors of cathepsin K, and their progress to date, are described.Keywords
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