LYMPHOCYTE TRAFFIC WITHIN THE BONE-MARROW AND SELECTIVE RETENTION OF ALLOREACTIVE CELLS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 27  (6) , 369-375
Abstract
Earlier studies showed that large numbers of isotopically labeled [rat] thoracic duct lymphocytes (TDL) enter the bone marrow (BM) within hours of injection but depart equally as rapidly by 12-24 h. The significance of this rapid flux was investigated. Early (1/2-2 h) after the i.v. injection of TDL, BM contained T [thymus-derived] cells capable of initiating a graft-vs.-host (GVH) reaction in F1 hybrids and in other experiments memory cells against human serum albumin (HSA). GVH and memory cell activity had markedly declined in the BM by 12 h. In contrast to the rapid departure of TDL from syngeneic BM, F1 hybrid BM retained parental lymphocytes with GVH activity for alloantigens of the opposite parent. F1 hybrid BM under these circumstances supported the transformation and proliferation of lymphocytes activated in situ by alloantigens. The selectively retained T cells also reacted to 3rd party alloantigens. TDL with memory for HSA were retained in the BM of F1 hybrids. The BM is a site in which alloreactive immune responses may be initiated or sustained.

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