Decline in Mixed Lymphocyte Reactivity of Spleen Cells from Aged Mice of a Long-Lived Strain
Open Access
- 1 May 1973
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 110 (5) , 1216-1221
- https://doi.org/10.4049/jimmunol.110.5.1216
Abstract
The mixed lymphocyte reaction was measured in male C57BL/6J mice 21 to 25 weeks, 90 to 94 weeks, and 150 weeks of age. A statistically significant decline in reactivity was noted for the oldest group of mice, compared to both younger groups. These results are interpreted in relation to survival patterns and age-specific incidences of spontaneous neoplasia in this long-lived strain.Keywords
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