Growth hormone-induced nitrogen retention in children of short stature.

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Abstract
The N retention produced by administration of HGH [human growth hormone] was measured in 22 short children, 10 of whom were hypopituitary dwarfs. Increased N retention was recorded in all but 2 of the children. It was greater in the hypopituitary group, and the effect persisted for a longer period after withdrawal of HGH. In the non-hypopituitary children a lesser degree of N retention was followed by a rapid return of N excretion to pre-HGH levels, or above. Through the N retention results for the 2 groups were not widely separated, no actual overlap occurred. N retention in the non-hypopituitary children was not related to HGH dose rate or protein intake during the test. In the hypopituitary children N retention was similarly unrelated to HGH dose rate, but a positive relation to protein intake was suggested. The correlation coefficient, however, was not significant.